We investigated the effects of ovarectomy and the steroid hormones estrogen and testosterone on the in vivo expression of heavy (MHC) and light (MLC) chains of myosin in the heart, uterus, and aorta of rats. In the heart, ovarectomy decreased alpha-MHC expression, while both steroid hormones normali
Regulation of smooth muscle myosin
โ Scribed by Trybus, Kathleen M.
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 447 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0886-1544
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In vertebrate and invertebrate nonmuscle myosins, light-and heavy-chain phosphorylation regulate myosin assembly into filaments, and interaction with actin. Vertebrate non-muscle myosins can exist in vitro in three main states, either 'folded ' (assembly-blocked) or ' extended' (assembly-competen t)
The aim of our study was to determine the relation between alternatively spliced myosin heavy chain (MHC) isoforms and the contractility of smooth muscle. The relative amount of MHC with an alternatively spliced insert in the 5 ' (amino terminal) domain was determined on the protein level using a pe