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Regulation of mannose 6-phosphate/insulin-like growth factor II receptor distribution by activators and inhibitors of protein kinase C

✍ Scribed by Thomas BRAULKE; Stefanie TIPPMER; Huey-Jiun CHAO; Kurt von FIGURA


Book ID
115127858
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
919 KB
Volume
189
Category
Article
ISSN
1432-1327

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The ability of acute insulin treatment to elicit a redistribution of the liver insulin-like growth factor-II/ mannose 6-phosphate (IGF-II/M6P) receptor has been studied in rats, using cell fractionation. Injection of insulin (0.4 -50 g) led to a time-and dose-dependent decrease in IGF-II binding act