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Decreased prostate cancer cell migration by inhibition of the insulin-like growth factor II/Mannose-6-Phosphate receptor

โœ Scribed by Christopher P Evans; Fred Elfman; Gerald Cunha; Marc A Shuman


Book ID
117724745
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
337 KB
Volume
3
Category
Article
ISSN
1078-1439

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The soluble form of the insulin-like growth factor II (IGF-II)/mannose 6-P (IGF-II/ M6P) receptor is released by cells in culture and circulates in the serum. It retains its ability to bind IGF-II and blocks IGF-II-stimulated DNA synthesis in isolated rat hepatocytes. Because these cells are not nor