✦ LIBER ✦

Regulation of intestinal stem cells in mammals and Drosophila

✍ Scribed by Ping Wang; Steven X. Hou

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 118 KB
Volume: 222
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21928

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The digestive systems in mammals and Drosophila are quite different in terms of their complexity and organization, but their biological functions are similar. The Drosophila midgut is a functional equivalent of the mouse small intestine. Adult intestinal stem cells (ISCs) have been identified in both the mouse small intestine and Drosophila midgut. The anatomy and cell renewal in the Drosophila midgut are similar to those in the mouse small intestine: the intestinal epithelium in both systems is a tube composed of epithelial cells with absorptive and secretory functions; the Notch signaling controls absorptive versus secretory fate decisions in the intestinal epithelium; cell renewal in both systems starts from stem cells in the basal cell layer, and the differentiated cells then move toward the lumen. However, it is clear that the stem cells in the two systems are regulated in different ways. In this review, we will compare cell renewal and stem cell regulation in the two systems. J. Cell. Physiol. 222:33–37, 2010. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

The origin of intestinal stem cells in D

The origin of intestinal stem cells in Drosophila

✍ Craig A. Micchelli 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 365 KB 👁 1 views

## Abstract Renewing tissues in the adult organism such as the gastrointestinal (GI) epithelium depend on stem cells for epithelial maintenance and repair. Yet, little is known about the developmental origins of adult stem cells and their niches. Studies of Drosophila adult midgut precursors (AMPs)

Another notch in stem cell biology: Dros

Another notch in stem cell biology: Drosophila intestinal stem cells and the specification of cell fates

✍ Andrew A. Wilson; Darrell N. Kotton 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 70 KB 👁 2 views

## Abstract Previous work has suggested that many stem cells can be found in microanatomic niches, where adjacent somatic cells of the niche control the differentiation and proliferation states of their resident stem cells. Recently published work examining intestinal stem cells (ISCs) in the adult

Intestinal stem cell asymmetric division

Intestinal stem cell asymmetric division in the Drosophila posterior midgut

✍ Steven X. Hou 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB 👁 1 views

## Abstract Over the past 2 years, our understanding of intestinal stem cells in the __Drosophila__ posterior midgut has advanced greatly. In this review, I will focus on the establishment of these stem cells in their niche during development and the molecular mechanisms that regulate their asymmet

Regulation of reactive oxygen species in

Regulation of reactive oxygen species in stem cells and cancer stem cells

✍ Chiharu I. Kobayashi; Toshio Suda 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 485 KB 👁 2 views

## Abstract Stem cells are defined by their ability to self‐renew and their multi‐potent differentiation capacity. As such, stem cells maintain tissue homeostasis throughout the life of a multicellular organism. Aerobic metabolism, while enabling efficient energy production, also generates reactive

Regulation of stemness and stem cell nic

Regulation of stemness and stem cell niche of mesenchymal stem cells: Implications in tumorigenesis and metastasis

✍ Nastaran Z. Kuhn; Rocky S. Tuan 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 272 KB 👁 1 views

## Abstract Human mesenchymal stem cells (MSCs) derived from adult tissues have been considered a candidate cell type for cell‐based tissue engineering and regenerative medicine. These multipotent cells have the ability to differentiate along several mesenchymal lineages and possibly along non‐mese

Adult neurogenesis and neural stem cells

Adult neurogenesis and neural stem cells of the central nervous system in mammals

✍ Philippe Taupin; Fred H. Gage 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 376 KB 👁 1 views

Neural stem cells (NSCs) are the self-renewing, multipotent cells that generate neurons, astrocytes, and oligodendrocytes in the nervous system (Fig. 1a). Over the past decades, the confirmation that neurogenesis occurs in discrete areas of the adult brain and that NSCs reside in the adult brain has