✦ LIBER ✦

The origin of intestinal stem cells in Drosophila

✍ Scribed by Craig A. Micchelli

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 365 KB
Volume: 241
Category: Article
ISSN: 1058-8388
DOI: 10.1002/dvdy.22759

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Renewing tissues in the adult organism such as the gastrointestinal (GI) epithelium depend on stem cells for epithelial maintenance and repair. Yet, little is known about the developmental origins of adult stem cells and their niches. Studies of Drosophila adult midgut precursors (AMPs), a population of endodermal progenitors, demonstrate that adult intestinal stem cells (ISCs) arise from the AMP lineage and provide insight into the stepwise process by which the adult midgut epithelium is established during development. Here, I review the current literature on AMPs, where local, inductive and long‐range humoral signals have been found to control progenitor cell behavior. Future studies will be necessary to determine the precise mechanism by which adult intestinal stem cells are established in the endodermal lineage. Developmental Dynamics 241:85–91, 2012. © 2011 Wiley Periodicals, Inc.

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