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Adult neurogenesis and neural stem cells of the central nervous system in mammals

✍ Scribed by Philippe Taupin; Fred H. Gage

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
376 KB
Volume
69
Category
Article
ISSN
0360-4012

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✦ Synopsis

Neural stem cells (NSCs) are the self-renewing, multipotent cells that generate neurons, astrocytes, and oligodendrocytes in the nervous system (Fig. 1a). Over the past decades, the confirmation that neurogenesis occurs in discrete areas of the adult brain and that NSCs reside in the adult brain has overturned the long-held dogma that we are born with a certain number of nerve cells and that the brain cannot generate new neurons and renew itself. In this article, we review the evidence that neurogenesis occurs in the adult mammalian central nervous system (CNS) and that the adult CNS contains NSCs.

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in Sweden, where he has been active throughout his career. He initially trained as a neuroanatomist, and became interested in brain regeneration and repair in the early seventies. Together with his close collaborators Ulf Stenevi, Olle Lindvall, Fred Gage (now at the Salk institute in La Jolla, USA)

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