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Mechanism of stem cells in the central nervous system

✍ Scribed by Clas B. Johansson

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
246 KB
Volume
196
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Injury to the central nervous system (CNS) can result in severe functional impairment. The brain and spinal cord, which constitute the CNS, have been viewed for decades as having a very limited capacity for regeneration. However, over the last several years, the body of evidence supporting the concept of regeneration and continuous renewal of neurons in specific regions of the CNS has increased. This evidence has significantly altered our perception of the CNS and has offered new hope for possible cell therapy strategies to repair lost function. Transplantation of stem cells or the recruitment of endogenous stem cells to repair specific regions of the brain or spinal cord is the next exciting research challenge. However, our understanding of the existing stem cell pool in the adult CNS remains limited. This review will discuss the identification and characterization of CNS stem cells in the adult brain and spinal cord. J. Cell. Physiol. 196: 409–418, 2003. Β© 2003 Wiley‐Liss, Inc.

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in Sweden, where he has been active throughout his career. He initially trained as a neuroanatomist, and became interested in brain regeneration and repair in the early seventies. Together with his close collaborators Ulf Stenevi, Olle Lindvall, Fred Gage (now at the Salk institute in La Jolla, USA)