✦ LIBER ✦

The use of neural stem cells for gene therapy in the central nervous system

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 70 KB
Volume: 1
Category: Article
ISSN: 1099-498X
DOI: 10.1002/(sici)1521-2254(199905/06)1:3<223::aid-jgm38>3.0.co;2-0

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✦ Synopsis

in Sweden, where he has been active throughout his career. He initially trained as a neuroanatomist, and became interested in brain regeneration and repair in the early seventies. Together with his close collaborators Ulf Stenevi, Olle Lindvall, Fred Gage (now at the Salk institute in La Jolla, USA) and Steve Dunnett (at the Brain Repair Centre in Cambridge, UK) he started to explore the use of fetal neural transplants for neuronal replacement and functional repair in the damaged CNS, which led to the ®rst application of dopamine neuron transplants in patients with advanced Parkinson's disease. Cell transplantation as a tool for in vivo gene therapy has been part of the Lund program since the early nineties.

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