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Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome)

✍ Scribed by J.L. Fiedler; C.J. Epstein; S.I. Rapoport; R. Caviedes; P. Caviedes


Book ID
114001584
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
631 KB
Volume
658
Category
Article
ISSN
0006-8993

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## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin