## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin
✦ LIBER ✦
Cell Lines Derived from Hippocampal Neurons of the Normal and Trisomy 16 Mouse Fetus (a Model for Down Syndrome) Exhibit Neuronal Markers, Cholinergic Function, and Functional Neurotransmitter Receptors
✍ Scribed by Ana Marı́a Cárdenas; Christian Arriagada; David D. Allen; Raúl Caviedes; José F. Cortes; José Martin; Eduardo Couve; Stanley I. Rapoport; Takeshi Shimahara; Pablo Caviedes
- Book ID
- 115607775
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 235 KB
- Volume
- 177
- Category
- Article
- ISSN
- 0014-4886
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## Abstract We report the establishment of continuously growing cell lines from spinal cords of normal and trisomy 16 fetal mice. We show that both cell lines, named M4b (derived from a normal animal) and MTh (trisomic) possess neurological markers by immunohistochemistry (neuron specific enolase,