Reductone and the Synthesis of Pteridines
✍ Scribed by FORREST, H. S.; WALKER, JAMES
- Book ID
- 109556829
- Publisher
- Nature Publishing Group
- Year
- 1948
- Tongue
- English
- Weight
- 213 KB
- Volume
- 161
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/161721a0
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
## Abstract A new synthesis of pteridines possessing a (substituted) (__Z__)‐3‐hydroxyprop‐1‐enyl group at C(6) is based on the acylation of 4‐amino‐5‐nitrosopyrimidines with dienoic acid chlorides, followed by a high‐yielding intramolecular hetero‐__Diels–Alder__ cycloaddition and cleavage of the
## Abstract Reaction of 2‐aminopyrazine 1 with isothiocyanate, isocyanate or dithioketal reagent furnished pteridines **3,4** in good yield. Thioxo compound **3a** was chlorinated, methylated and subsequently displaced by amines. A simple one‐step synthesis of heterocondensed pteridines **8–13** by