This paper describes the rational design and synthesis of novel inhibitors of human steroid 5a-reductase. Steroidal nitrones were synthesised via an eight-step sequence from epiandrosterone and were tested for activity against type I and II 5a-reductase isozymes. Judicious placement of the nitrone i
Reduction of fertilizing capacity of epididymal spermatozoa by 5α-steroid reductase inhibitors
✍ Scribed by J. Cohen; Marja P. Ooms; J. T. M. Vreeburg
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 226 KB
- Volume
- 37
- Category
- Article
- ISSN
- 1420-682X
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## Abstract 17β‐[N‐(1,1‐Dimethylethyl)carbamoyl]androsta‐3,5‐diene‐4‐^14^C‐3‐carboxylic acid ([^14^C]SK&F 105657) was prepared __via__ a three‐step sequence (t‐butyl amidation, triflation and carbomethoxylation) starting from androst‐4‐en‐3‐one‐4‐^14^C‐17β‐carboxylic acid. Its A‐ring aromatic analo