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Recurrence of Budd–Chiari syndrome after liver transplantation in paroxysmal nocturnal hemoglobinuria

✍ Scribed by MatthiasJ. Bahr; Jörg Schubert; JörgS. Bleck; UweJ.F. Tietge; Bita Boozari; ReinholdE. Schmidt; Jürgen Klempnauer; ChristianP. Strassburg; MichaelP. Manns


Book ID
105840610
Publisher
Springer
Year
2002
Tongue
English
Weight
656 KB
Volume
16
Category
Article
ISSN
0934-0874

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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hemolytic anemia caused by somatic mutations in the phosphatidylinositol glycan-complementation class A gene and the resulting absence of a key complement regulatory protein, CD59. Affected red blood cells in patients with PNH undergo int