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Budd-Chiari syndrome in a paroxysmal nocturnal hemoglobinuria patient with previous cerebral venous thrombosis

✍ Scribed by Antonella Tufano; Nicola Macarone Palmieri; Ernesto Cimino; Fiorella Alfinito; Anna Maria Cerbone


Publisher
Springer Milan
Year
2008
Tongue
English
Weight
129 KB
Volume
4
Category
Article
ISSN
1828-0447

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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hemolytic anemia caused by somatic mutations in the phosphatidylinositol glycan-complementation class A gene and the resulting absence of a key complement regulatory protein, CD59. Affected red blood cells in patients with PNH undergo int