Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired chronic hemolytic anemia associated with an unusual susceptibility to hemolytic crisis, infection, and venous thrombosis which would be aggravated by a number of factors including surgery. We report a case of PNH undergoing percutaneous transl
Microvascular thrombosis in the hepatic vein of a patient with paroxysmal nocturnal hemoglobinuria
β Scribed by Hideyoshi Noji; Tsutomu Shichishima; Masatoshi Okamoto; Akiko Shichishima-Nakamura; Hayato Matsumoto; Hiroko Tajima; Kazuei Ogawa; Yukio Maruyama
- Publisher
- Carden Jennings Publishing
- Year
- 2007
- Tongue
- English
- Weight
- 482 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0925-5710
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A patient with paroxysmal nocturnal hemoglobinuria developed lactic acidosis associated with severe anemia. The lactic acidosis corrected after blood transfusion. In the absence of shock, sepsis, or other identifiable causes of lactic acidosis, the severe anemia (hemoglobin 1.2 g/dl) appeared to be
## Abstract Until recently, there has been no specific therapy for PNH with clinical management mainly supportive in terms of cytopenias and control of thrombotic risk. Currently, the only curative procedure for PNH is bone marrow transplantation although for the majority of patients the associated