## Abstract A bioactive and resorbable scaffold is necessary to exhibit the osteoinductive potency of recombinant human bone morphogenetic proteinโ2 (rhBMPโ2). In a previous study, we found that synthetic octacalcium phosphate (OCP) enhances bone regeneration and is replaced by newly formed bone af
Recombinant human bone morphogenetic protein
โ Scribed by Raj K. Shah; Valeria M. Moncayo; Robert D. Smitson; Claude Pierre-Jerome; Michael R. Terk
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 191 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0364-2348
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The study reported describes a combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) and collagen (C) to regenerate bone. Unilateral critical-sized defects (CSDs) were prepared in radii of 32 skeletally mature New Zealand white rabbits. Rabbits were divided evenly among four treatm
## Abstract Bone morphogenetic protein (BMP)โ2 plays an important role in bone growth and regeneration; however, BMPโ2 is easily lost by diffusion through body fluid and has some inhibitory pathways. To address this problem, we previously immobilized recombinant human BMPโ2 (rhBMPโ2) on succinylate