Bisphosphonate incadronate inhibits maturation of ectopic bone induced by recombinant human bone morphogenetic protein 2
β Scribed by Lin Gong; Kazuto Hoshi; Sadakazu Ejiri; Tamio Nakajima; Susumu Shingaki; Hidehiro Ozawa
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 439 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0914-8779
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Recombinant human bone morphogenetic protein-2 (rhBMP-2) was encapsulated in biodegradable poly(DL-lactide-co-glycolide) (PLGA) capsules to regenerate bone by controlling the release rate of rhBMP-2. The rhBMP-2/PLGA capsules containing 12 g of rhBMP-2 were implanted in seven 15-mm segmental defects
## Abstract Bone morphogenetic proteins (BMP) stimulate osteoblast differentiation by signal transduction via three BMP receptors (BMPRβIA, βIB, and βII). Several growth factors, including transforming growth factorβΞ²1 (TGFβΞ²1), fibroblast growth factorβ2 (FGFβ2) and plateletβderived growth factorβ