Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration

✍ Scribed by Hollinger, Jeffrey O. ;Schmitt, John M. ;Buck, David C. ;Shannon, Robert ;Joh, Seong-Pil ;Zegzula, H. Daniel ;Wozney, John

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 312 KB
• Volume: 43
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199824)43:4<356::aid-jbm3>3.0.co;2-7

✦ Synopsis

The study reported describes a combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) and collagen (C) to regenerate bone. Unilateral critical-sized defects (CSDs) were prepared in radii of 32 skeletally mature New Zealand white rabbits. Rabbits were divided evenly among four treatments: autograft, absorbable C (Helistat), 35 mg of rhBMP-2 combined with absorbable C (rhBMP-2/C), and untreated CSDs. The two euthanasia periods were 4 and 8 weeks. Radiographs were taken the day of surgery, every 2 weeks, and at term and the percent of radiopacity was measured. Data analysis revealed a time-dependent increase in the percent radiopacity with rhBMP-2/C. Histological examination revealed the rhBMP-2/C treatment regenerated osseous contour by 8 weeks. According to quantitative histomorphometry, the CSD and C groups had significantly less new bone than either autograft or rhBMP-2/C (p °0.05). The results suggest that rhBMP-2/C could be an effective therapy to restore segmental bone defects.