Receptor usage in myelin phagocytosis by microglia and macrophages
โ Scribed by K. Mosley; M.N. Woodroofe; M.L. Cuzner
- Book ID
- 119109092
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 134 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0165-5728
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Macrophages/microglia are the key effector cells in myelin removal. Differences exist in the amount and time course of myelin uptake in the central (CNS) and peripheral nervous system (PNS), the basis of this difference, however, is not yet clarified. In the present experiments we studi
Previous experiments from this laboratory have shown that peritoneal macrophages in culture will phagocytize myelin. Myelin preopsonized with myelin antibodies is phagocytized to a much greater extent than untreated myelin, indicating that macrophages ingest myelin by an Fc receptor. The present wor
## Abstract The removal by phagocytosis of degenerated myelin is central for repair in Wallerian degeneration that follows traumatic injury to axons and in autoimmune demyelinating diseases (e.g., multiple sclerosis). We tested for roles played by the cAMP cascade in the regulation of myelin phagoc