## Abstract The removal by phagocytosis of degenerated myelin is central for repair in Wallerian degeneration that follows traumatic injury to axons and in autoimmune demyelinating diseases (e.g., multiple sclerosis). We tested for roles played by the cAMP cascade in the regulation of myelin phagoc
Complement-receptor-3 and scavenger-receptor-AI/II mediated myelin phagocytosis in microglia and macrophages
✍ Scribed by Fanny Reichert; Shlomo Rotshenker
- Book ID
- 117688478
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 129 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0969-9961
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## Abstract The removal of degenerated myelin is essential for repair in Wallerian degeneration that follows traumatic injury to axons and in autoimmune demyelinating diseases (e.g., multiple sclerosis). Microglia can remove degenerated myelin through phosphatidylinositol‐3‐kinase (PI3K)‐dependent
## Abstract Complement‐receptor‐3 (CR3/MAC‐1), scavenger‐receptor‐AI/II (SRAI/II), and Fcγ‐receptor (FcγR) can mediate myelin phagocytosis in macrophages and microglia. Paradoxically, after injury to CNS axons these receptors are expressed but myelin is not phagocytosed, suggesting that phagocytosi