Receptor-mediated phagocytosis of myelin by macrophages and microglia: Effect of opsonization and receptor blocking agents
โ Scribed by K. Mosley; M. L. Cuzner
- Book ID
- 110549025
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 486 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0364-3190
No coin nor oath required. For personal study only.
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## Abstract Macrophages/microglia are the key effector cells in myelin removal. Differences exist in the amount and time course of myelin uptake in the central (CNS) and peripheral nervous system (PNS), the basis of this difference, however, is not yet clarified. In the present experiments we studi
## Abstract The removal by phagocytosis of degenerated myelin is central for repair in Wallerian degeneration that follows traumatic injury to axons and in autoimmune demyelinating diseases (e.g., multiple sclerosis). We tested for roles played by the cAMP cascade in the regulation of myelin phagoc