Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease
β Scribed by Shlomo Rotshenker
- Book ID
- 111639690
- Publisher
- Humana Press Inc
- Year
- 2003
- Tongue
- English
- Weight
- 108 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0895-8696
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## Abstract The removal of degenerated myelin is essential for repair in Wallerian degeneration that follows traumatic injury to axons and in autoimmune demyelinating diseases (e.g., multiple sclerosis). Microglia can remove degenerated myelin through phosphatidylinositolβ3βkinase (PI3K)βdependent
## Abstract The removal by phagocytosis of degenerated myelin is central for repair in Wallerian degeneration that follows traumatic injury to axons and in autoimmune demyelinating diseases (e.g., multiple sclerosis). We tested for roles played by the cAMP cascade in the regulation of myelin phagoc