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Recent developments in the field of A2A and A3 adenosine receptor antagonists

✍ Scribed by Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Andrea Bovero; Barbara Avitabile; Delia Preti; Francesca Fruttarolo; Romeo Romagnoli; Katia Varani; Pier Andrea Borea


Book ID
108422062
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
442 KB
Volume
38
Category
Article
ISSN
0223-5234

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Recent developments in the field of A3 a
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## Abstract Adenosine is an endogenous modulator of a large variety of physiological functions through the interaction with specific cell membrane G‐protein‐coupled receptors classified as A~1~, A~2A~, A~2B~, and A~3~. Activation of A~3~ receptors has been shown to stimulate phospholipase C and to

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Selective and potent antagonists for the A 2A adenosine receptors have been described recently. The most potent compounds have a triazolo-pyrimidine structure, whereas 8-styryl-xanthines usually possess lower affinity at the A 2A receptor. We have examined the quantitative structure activity relatio