Recent developments in the field of A2A and A3 adenosine receptor antagonists
β Scribed by Pier Giovanni Baraldi; Mojgan Aghazadeh Tabrizi; Andrea Bovero; Barbara Avitabile; Delia Preti; Francesca Fruttarolo; Romeo Romagnoli; Katia Varani; Pier Andrea Borea
- Book ID
- 108422062
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 442 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0223-5234
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π SIMILAR VOLUMES
## Abstract Adenosine is an endogenous modulator of a large variety of physiological functions through the interaction with specific cell membrane Gβproteinβcoupled receptors classified as A~1~, A~2A~, A~2B~, and A~3~. Activation of A~3~ receptors has been shown to stimulate phospholipase C and to
Selective and potent antagonists for the A 2A adenosine receptors have been described recently. The most potent compounds have a triazolo-pyrimidine structure, whereas 8-styryl-xanthines usually possess lower affinity at the A 2A receptor. We have examined the quantitative structure activity relatio