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Highlights on the Development of A2A Adenosine Receptor Agonists and Antagonists

✍ Scribed by Gloria Cristalli; Barbara Cacciari; Diego Dal Ben; Catia Lambertucci; Stefano Moro; Giampiero Spalluto; Rosaria Volpini


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
1014 KB
Volume
2
Category
Article
ISSN
1860-7179

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A step-wise CoMFA-based procedure was applied to a series of 51 C2-oxyadenosines in order to select the most predictive conformation for binding to A 2A adenosine receptor. The highest correlation and predictive power was found for conformers with the side chain at the 2position oriented in the dire