Rearranging pre-B-cell genes
β Scribed by Chris Morrison
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 254 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0167-5699
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Molecular genetic analysis of rearranging antigen-receptor genes in non-Hodgkin's lymphomas has revealed the clonality and lineage in the majority of cases. In an analogous approach, we sought to apply gene rearrangement analysis to Hodgkin's disease to understand better the clonality and origin of
We have examined 69 B-cell non-Hodgkin's lymphomas (NHL) for rearrangements of the immunoglobulin (Ig) or Tcell antigen receptor (TCR) genes. The lymphomas were assigned to the categories of the Kiel classification and their B-cell nature was confirmed by immunostaining. Only 2 cases (with CLL) disp
The antigen receptor on B lymphocytes is the product of a series ~of gene rearrangements which ends when a functional receptor gene is assembled. Recent work has shown that the receptor-associated molecules Iga and Igl3 provide the signals that lead to inhibition of further recombination. Furthermor