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Control of immunoglobulin gene rearrangements in developing B cells

✍ Scribed by Fotini Papavasiliou; Mila Jankovic; Shiaoching Gong; Michel C Nussenzweig

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
582 KB
Volume
9
Category
Article
ISSN
0952-7915

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✦ Synopsis

The antigen receptor on B lymphocytes is the product of a series ~of gene rearrangements which ends when a functional receptor gene is assembled. Recent work has shown that the receptor-associated molecules Iga and Igl3 provide the signals that lead to inhibition of further recombination. Furthermore, Igl~ has been implicated in initiating the last step of the recombination reaction.

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