The antigen receptor on B lymphocytes is the product of a series ~of gene rearrangements which ends when a functional receptor gene is assembled. Recent work has shown that the receptor-associated molecules Iga and Igl3 provide the signals that lead to inhibition of further recombination. Furthermor
Gene rearrangement and B-cell development
β Scribed by Jianzhu Chen; Frederick W. Alt
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 1018 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0952-7915
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This is a report on our attempt to use polymerase chain reaction (PCR) to detect rearrangement of the immunoglobulin gene in the tissue specimens obtained from 30 patients with non-Hodgkin's lymphomas. There were 20 B-cell lymphomas and 10 T-cell. All 20 B-cell lymphomas but none of the 10 T-cell ly