𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Heterogeneity of immunoglobulin gene rearrangements in B-cell lymphomas

✍ Scribed by M. Kneba; M. Bergholz; I. Bolz; M. Hulpke; R. Bätge; A. Schauer; G. Krieger

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
630 KB
Volume
45
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

We have examined 69 B-cell non-Hodgkin's lymphomas (NHL) for rearrangements of the immunoglobulin (Ig) or Tcell antigen receptor (TCR) genes. The lymphomas were assigned to the categories of the Kiel classification and their B-cell nature was confirmed by immunostaining. Only 2 cases (with CLL) displayed clonal Tp-chain TCR gene rearrangements together with rearranged heavy-and light-chain Ig genes. The remaining 67 lymphomas had a germline f3-chain TCR-gene configuration. Three different patterns of Ig gene rearrangements were identified; (A) presence of both heavyand light-chain rearrangements (H+L+); (B) rearrangement of heavy-chain gene only (H+L-); (C) heavy-and light-chain genes in germline configuration (H-L-). All the 45 low-grade NHLr and the 4 immunoblastic lymphomas exhibited pattern A and all had their kappa gene rearranged or deleted. Of 24 low-grade lymphomas tested, I 3 (54%) had an additional rearrangement of the lambda light-chain gene. In contrast, the I9 high-grade centroblastic (cb) B-NHLs had distinct patterns of Ig-gene rearrangement: I 2 with pattern A, 4 with B and 2 with C. In this group only 2 of 17 (12%) cases analyzed had evidence of lambda light-chain rearrangement whereas I 2 of 18 (67%) had a kappa gene rearrangement or deletion. In one case expressing slgMllambda and with heavy chain Igrearrangement, no DNA was available for Ig light-chain analysis. 'Two cases also showed T rearrangements. The other 13 lymphomas lacked evidence of monoclonal T,, gene rearrangements-21n one case (10, Table 11) DNA for light-chain and TCR-gene anafysis was not available. This case expressed sIgWlambda and had 1 1" allele remanged.-'These cases had germ-line configuration of both the T , and T-y-TCR genes and did not express Ig.

📜 SIMILAR VOLUMES

Detection of immunoglobulin gene rearran
Detection of immunoglobulin gene rearrangement in B-cell lymphomas by polymerase chain reaction gene amplification
✍ Dr Raymond Liang; Vivian Chan; T. K. Chan; Thomas Wong; David Todd 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 654 KB

This is a report on our attempt to use polymerase chain reaction (PCR) to detect rearrangement of the immunoglobulin gene in the tissue specimens obtained from 30 patients with non-Hodgkin's lymphomas. There were 20 B-cell lymphomas and 10 T-cell. All 20 B-cell lymphomas but none of the 10 T-cell ly

Control of immunoglobulin gene rearrange
Control of immunoglobulin gene rearrangements in developing B cells
✍ Fotini Papavasiliou; Mila Jankovic; Shiaoching Gong; Michel C Nussenzweig 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 582 KB

The antigen receptor on B lymphocytes is the product of a series ~of gene rearrangements which ends when a functional receptor gene is assembled. Recent work has shown that the receptor-associated molecules Iga and Igl3 provide the signals that lead to inhibition of further recombination. Furthermor

Gene rearrangements in T-cell lymphoblas
Gene rearrangements in T-cell lymphoblastic lymphoma
✍ Pilozzi, Emanuela; M�ller-Hermelink, Hans-Konrad; Falini, Brunangelo; de Wolf-Pe 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB 👁 2 views

This study presents an examination of the Ig heavy chain (IgH) and T-cell receptor gamma (TCR ) genes in a series of 39 CD3-positive T-cell acute lymphoblastic leukaemia (ALL) cases with and without co-expression of CD79a; 30/39 cases had a rearrangement of the TCR genes and two of these 30 cases al