Rearrangement of immunoglobulin, T-cell receptor, and bcl-2 genes in malignant lymphomas in Hong Kong
โ Scribed by Raymond Liang; Vivian Chan; T. K. Chan; Edmond Chiu; David Todd
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 444 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
A unique case with diffuse mixed malignant lymphoma was investigated for gene rearrangement on the level of T-cell receptor (TCR), heavy chain immunoglobulin (Ig), and both light chains. Cell phenotype was examined with immunofluorescence techniques using antibodies against surface immunoglobulins (
Bcl-6 (LAZ-3) and Bcl-2 gene rearrangements have been respectively reported in 20-35 per cent and 10-25 per cent of diffuse large B-cell lymphomas (DLBCLs). Although these genetic lesions have been associated with different clinical outcomes (i.e., more favourable in Bcl-6 rearranged cases and poore