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Gene rearrangements in T-cell lymphoblastic lymphoma

✍ Scribed by Pilozzi, Emanuela; M�ller-Hermelink, Hans-Konrad; Falini, Brunangelo; de Wolf-Peeters, Christine; Fidler, Carrie; Gatter, Kevin; Wainscoat, James

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
215 KB
Volume
188
Category
Article
ISSN
0022-3417

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✦ Synopsis

This study presents an examination of the Ig heavy chain (IgH) and T-cell receptor gamma (TCR ) genes in a series of 39 CD3-positive T-cell acute lymphoblastic leukaemia (ALL) cases with and without co-expression of CD79a; 30/39 cases had a rearrangement of the TCR genes and two of these 30 cases also demonstrated an IgH rearrangement. No cases had solely an IgH rearrangement. The conclusion of the study is that lymphoblastic lymphoma cases that are positive for CD3 are of T-cell lineage, regardless of CD79a expression.

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## Abstract Clonal T‐cell receptor (TCR) gamma and delta gene rearrangements were studied in 40 T‐ALL cases (pediatrics, 29; adults, 11) using PCR with homo‐heteroduplex analysis. At least one clonal TCRG or TCRD rearrangement was detected in 34 (85%) cases. TCR gamma (__TCRG__) rearrangement was d