Richter syndrome with two B cell clones possessing different surface immunoglobulins and immunoglobulin gene rearrangements
✍ Scribed by Shuji Tohda; Toshiya Suzuki; Kaoru Nagata; Takashi Kamiyama; Yasufumi Imai; Nobuo Nara; Nobuo Aoki; Tomohiro Morio
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 394 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
A patient with two populations of B cell malignancy In the bone marrow Is reported. One population consisted of mature small lymphocytes, expressing surface IgM + D, A and proliferating very slowly. The other population consisted of abnormal large lymphoid cells, expressing surface IgM, K and proliferating actively. We considered the former as chronlc lymphocytic leukemia cells and the latter as malignant lymphoma cells. There fore, this case was considered as Richter syndrome. The analysis of immunoglobulin heavy chain gene rearrangement showed the d h r e n t patterns between the two populatlons. It suggested that the two populations arose from the different origins. We discussed the genetic relationship between the two clones of Richter syndrome referring to other reported cases.