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Reactions of 4,5-dicyanopyridazine with alkynes and enamines: A new straightforward complementary route to 4-mono- and 4,5-disubstituted phthalonitriles

โœ Scribed by Stefania Turchi; Rodolfo Nesi; Donatella Giomi


Book ID
108378875
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
334 KB
Volume
54
Category
Article
ISSN
0040-4020

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Reactions of 4,5-Dicyanopyridazine with Alkynes and Enamines: A New Straightforward Complementary Route to 4-Mono-and 4,5-Disubstituted Phthalonitriles. -The title pyridazine (I) is a valuable synthon for alternative direct approaches to phthalonitriles from dienophiles of type (II) and (IV). The n

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The title conversions were shown to involve as key intermediates new dicyanodiene systems, that can be isolated in high fields under mild conditions; their structures, inferred from analytical and spectral data, were confirmed by an X-ray study. Some improvements for the synthetic methodology connec