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Reaction of 5-aminopyrazoles with β-dimethylaminopropiophenones. Synthesis of new pyrazolo[3,4-b]pyridines

✍ Scribed by J. Quiroga; B. Insuasty; S. Cruz; P. Hernandez; A. Bolaños; R. Moreno; Angelina Hormaza; Regina H. S. de Almeida

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
329 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Several new pyrazolo[3,4‐b]pyridines were obtained from the reaction of 5‐amino‐1‐aryl‐3‐methylpyrazoles 1 with β‐dimemylaminopropiophenones 2 in pyridine. The structure elucidation of 4,5‐dihydropyrazolo[3,4‐b]pyridines 3 is based on nmr measurements and X‐ray diffraction. The treatment of compounds 3 with N‐bromosuccinimide led to the formation of pyrazolo[3,4‐b]pyridines 4.

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