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An efficient synthesis of pyrazolo[3,4-b]pyrrolo[2,3-d]pyridines from 5-aminopyrazoles and cyclic β-keto ester

✍ Scribed by Raghunath B. Toche; Bhausaheb K. Ghotekar; Dhananjay B. Kendre; Muddassar A. Kazi; Madhukar N. Jachak

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
295 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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5‐Chloroethylpyrazolo[3,4‐b]pyridines were synthesized by condensation of 5‐aminopyrazoles with α‐acetyl γ‐butyrolactone followed by cyclization treating with phosphorous oxychloride. 5‐Chloroethyl‐pyrazolo[3,4‐b]pyridines, thus obtained, were then converted to the corresponded tricyclic pyrazolo[3,4‐b]‐pyrrolo[2,3‐d]pyridines by treating with some primary amines.

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✍ Masahiko Takahashi; Hironori Nagaoka; Kazuhiro Inoue 📂 Article 📅 2004 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 213 KB

## Abstract 5 or 7‐Trifluoromethyl‐1,2,3,4‐tetrahydropyrido[2,3‐__d__]pyrimidine‐2,4‐diones **3**, **5**, **10**, **13** and 4‐ or 6‐trifluoromethylpyrazolo[3,4‐__b__]pyridines **15**, **16**, **19**, **21** were prepared from 6‐aminouracils and 5‐aminopyrazoles, respectively, in good yields by the