ChemInform Abstract: An Efficient Synthesis of Pyrazolo[3,4-b]pyridine-4-spiroindolinones by a Three-Component Reaction of 5-Aminopyrazoles, Isatin, and Cyclic β-Diketones.
✍ Scribed by Jairo Quiroga; Sandra Portillo; Alfredo Perez; Jaime Galvez; Rodrigo Abonia; Braulio Insuasty
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 41 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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Reaction of 5-Aminopyrazoles with β-Dimethylaminopropiophenones. Synthesis of New Pyrazolo [3,4-b]pyridines. -Reaction of 5aminopyrazoles (I) with β-aminopropiophenones (II) provides a new and simple synthetic entry into the pyrazolo[3,4-b]pyridine ring system. Oxidation of the dihydro-products (II
## Abstract magnified image 5‐Chloroethylpyrazolo[3,4‐__b__]pyridines were synthesized by condensation of 5‐aminopyrazoles with α‐acetyl γ‐butyrolactone followed by cyclization treating with phosphorous oxychloride. 5‐Chloroethyl‐pyrazolo[3,4‐__b__]pyridines, thus obtained, were then converted to