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Synthesis of trifluoromethylated pyrido[2,3-d]pyrimidine-2,4-diones from 6-aminouracils and trifluoromethylated pyrazolo[3,4-b]-pyridines from 5-aminopyrazoles

✍ Scribed by Masahiko Takahashi; Hironori Nagaoka; Kazuhiro Inoue

Publisher
Journal of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
213 KB
Volume
41
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

5 or 7‐Trifluoromethyl‐1,2,3,4‐tetrahydropyrido[2,3‐d]pyrimidine‐2,4‐diones 3, 5, 10, 13 and 4‐ or 6‐trifluoromethylpyrazolo[3,4‐b]pyridines 15, 16, 19, 21 were prepared from 6‐aminouracils and 5‐aminopyrazoles, respectively, in good yields by the use of building blocks such as 4,4,4‐trifluoro‐1‐phenyl‐1,3‐butanedione, 1,1,1‐trifluoro‐4‐phenyl‐3‐buten‐2‐one, 4‐ethoxy‐1,1,1‐trifluoro‐3‐buten‐2‐one, and ethyl trifluoroacetoacetate.

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Synthesis of pyrazolo-annelated heterocy
Synthesis of pyrazolo-annelated heterocyclic ring compounds such as pyrazolo[3,4-b]pyridines and pyrazolo[4′,3′:5,6]-pyrido[2,3-d]pyrimidines
✍ Madhukar N. Jachak; Appasaheb B. Avhale; Ragunath B. Toche; Ram W. Sabnis 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 311 KB

## Abstract magnified image A series of pyrazolo[3,4‐__b__]pyridines has been synthesized by __Friedländer__ condensation of 5‐amino‐pyrazole‐4‐carbaldehyde **1** with active methylene compounds in basic medium. Pyrazolo[4′3′:5,6]pyrido‐[2,3‐__d__]pyrimidines have been synthesized from pyrazolo[3,