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Rat liver microsomal uptake and irreversible protein binding of [1,2-14C]vinyl bromide

✍ Scribed by H.M. Bolt; J.G. Filser; R.K. Hinderer

Book ID
116072331
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
567 KB
Volume
44
Category
Article
ISSN
0041-008X

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✍ M. Younes; C. -P. Siegers; J. G. Filser πŸ“‚ Article πŸ“… 1979 πŸ› Springer-Verlag 🌐 English βš– 261 KB

The irreversible binding of [14C]-bromobenzene to rat liver microsomal protein in vitro was inhibited by dithiocarb and DMSO. Dithiocarb suppressed this binding in a time- and concentration-dependent manner (I50 = 4.5 10(-5) M). DMSO reduced the degree of covalent binding by 61% from 5 x 10(-5) M to