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Effect of dithiocarb and dimethyl sulfoxide on irreversible binding of14C-bromobenzene to rat liver microsomal protein

โœ Scribed by M. Younes; C. -P. Siegers; J. G. Filser

Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
261 KB
Volume
42
Category
Article
ISSN
0340-5761

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โœฆ Synopsis

The irreversible binding of [14C]-bromobenzene to rat liver microsomal protein in vitro was inhibited by dithiocarb and DMSO. Dithiocarb suppressed this binding in a time- and concentration-dependent manner (I50 = 4.5 10(-5) M). DMSO reduced the degree of covalent binding by 61% from 5 x 10(-5) M to 8 x 10(-4) M. Dithiocarb was also effective in inhibiting irreversible binding of bromobenzene to liver protein in vivo. Our results are consistent with the hypothesis that dithiocarb exerts its antihepatotoxic efficacy by depressing microsomal mixed-function oxidase activity.

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โœ M. Younes; C. -P. Siegers ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 273 KB

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