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Irreversible binding of 5-hydroxytryptamine and 5-hydroxytryptophan metabolites to rat liver microsomal protein

✍ Scribed by Tomihiko Uemura; Hiroshi Matsushita; Masako Ozawa; Andrea Fiori; Enzo Chiesara

Book ID
115910437
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
388 KB
Volume
101
Category
Article
ISSN
0014-5793

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Dithiocarb and (+)-cyanidanol-3-prevented paracetamol-induced liver injury in rats in vivo. Both, as well as two other antihepatotoxic agents, deanol and DMSO, inhibited covalent binding of [3H]-paracetamol to rat liver microsomal proteins in vitro. Dithiocarb and (+)-cyanidanol-3 were the most effe