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Irreversible protein binding of [14C]imipramine with rat and human liver microsomes

✍ Scribed by Hermann Kappus; Herbert Remmer

Book ID
115772566
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
746 KB
Volume
24
Category
Article
ISSN
0006-2952

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πŸ“œ SIMILAR VOLUMES

Irreversible protein binding of14C-imipr
Irreversible protein binding of14C-imipramine in rats in vivo
✍ H. Kappus πŸ“‚ Article πŸ“… 1976 πŸ› Springer-Verlag 🌐 English βš– 320 KB

Forty-eight hours after a single dose of 14C-imipramine to rats, 14Cradioactivity could be measured in the following organs: liver > kidney > serum > fat > spleen > duodenum > lung > muscle and brain. Liver microsomes contained the main part of radioactivity derived from '4C-imipramine. After exhau

Effect of dithiocarb and dimethyl sulfox
Effect of dithiocarb and dimethyl sulfoxide on irreversible binding of14C-bromobenzene to rat liver microsomal protein
✍ M. Younes; C. -P. Siegers; J. G. Filser πŸ“‚ Article πŸ“… 1979 πŸ› Springer-Verlag 🌐 English βš– 261 KB

The irreversible binding of [14C]-bromobenzene to rat liver microsomal protein in vitro was inhibited by dithiocarb and DMSO. Dithiocarb suppressed this binding in a time- and concentration-dependent manner (I50 = 4.5 10(-5) M). DMSO reduced the degree of covalent binding by 61% from 5 x 10(-5) M to