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Irreversible protein binding of14C-imipramine in rats in vivo

โœ Scribed by H. Kappus

Publisher
Springer-Verlag
Year
1976
Tongue
English
Weight
320 KB
Volume
37
Category
Article
ISSN
0340-5761

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โœฆ Synopsis

Forty-eight hours after a single dose of 14C-imipramine to rats, 14Cradioactivity could be measured in the following organs: liver > kidney > serum > fat > spleen > duodenum > lung > muscle and brain. Liver microsomes contained the main part of radioactivity derived from '4C-imipramine.

After exhaustive extraction, only the proteins of liver, kidney, spleen, lung and serum contained measurable amounts of radioactive labeling. The greatest amount of ~4C-imipramine irreversibly bound to proteins was detected in liver microsomes.

The question, as to whether the irreversible protein binding of imipramine, if it occurs during therapy, results in toxic side-effects, is discussed.

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