𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo biotransformation and biliary excretion of 1-14C-acrylonitrile in rats

✍ Scribed by B. I. Ghanayem; A. E. Ahmed

Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
536 KB
Volume
50
Category
Article
ISSN
0340-5761

No coin nor oath required. For personal study only.

✦ Synopsis

1-14C-Acrylonitrile (VCN) was given orally to rats, 27% of the given dose was excreted in bile in 6 h. When 1-14C-VCN was given to overnight fasted or cobaltous chloride treated rats, a significant increase in the biliary excretion occurred. Pretreatment of rats with phenobarbital produced no change, while diethyl maleate pretreatment significantly decreased the portion of the dose excreted in bile in 6 h. Four metabolites of 1-]4C-VCN have been isolated from the collected bile, and characterized. The two major biliary metabolites were found to be glutathione (GSH) conjugates of VCN, indicating the importance of GSH in VCN biotransformation.

πŸ“œ SIMILAR VOLUMES

Excretion and distribution of thiazesim-
Excretion and distribution of thiazesim-14C with its biotransformation in vivo and in vitro
✍ J. Dreyfuss; J. R. Swoap; C. Chinn; S. M. Hess πŸ“‚ Article πŸ“… 1968 πŸ› John Wiley and Sons 🌐 English βš– 838 KB

Thiaze~im-1~C [5-(2-dimethylaminoethyl) -2,3dihydro -2henyl -1,5benzothiazepin-4 (5H)-one] was demonstrated to have been compEtely absorbed after administration to rats. After an i.p. dose of 30 mg. of thiazesimJC per kg. the drug was found in all the tissues that were examined; it was most concentr

Pharmacokinetics and biliary excretion o
Pharmacokinetics and biliary excretion of mitoxantrone in rats
✍ Xinning Yang; Marilyn E. Morris πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 147 KB

The objective of this investigation was to compare the observed biliary clearance (CL(b)) and % of dose excreted in the bile (PD(b)) of mitoxantrone with the predicted values obtained from quantitative structure pharmacokinetic relationship (QSPKR) models. Blood and bile samples were collected from