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Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites

✍ Scribed by Kivinen, Laura; Tsubari, Minna; Haapajärvi, Tarja; Datto, Michael B; Wang, Xiao-Fan; Laiho, Marikki

Book ID
110062389
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
457 KB
Volume
18
Category
Article
ISSN
0950-9232

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WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet