Rare-Variant Association Analysis: Study Designs and Statistical Tests
✍ Scribed by Lee, Seunggeung; Abecasis, Gonçalo R.; Boehnke, Michael; Lin, Xihong
- Book ID
- 125800366
- Publisher
- American Society of Human Genetics
- Year
- 2014
- Tongue
- English
- Weight
- 564 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0002-9297
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In anticipation of the availability of next-generation sequencing data, there has been increasing interest in association analysis of rare variants (RVs). Owing to the extremely low frequency of a RV, single variant-based analysis and many existing tests developed for common variants may not be suit
In anticipation of the availability of next-generation sequencing data, there is increasing interest in investigating association between complex traits and rare variants (RVs). In contrast to association studies for common variants (CVs), due to the low frequencies of RVs, common wisdom suggests th
## Abstract Genome‐wide association (GWA) studies have proved to be extremely successful in identifying novel common polymorphisms contributing effects to the genetic component underlying complex traits. Nevertheless, one source of, as yet, undiscovered genetic determinants of complex traits are th