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Meta-analysis of gene-level tests for rare variant association

✍ Scribed by Liu, Dajiang J; Peloso, Gina M; Zhan, Xiaowei; Holmen, Oddgeir L; Zawistowski, Matthew; Feng, Shuang; Nikpay, Majid; Auer, Paul L; Goel, Anuj; Zhang, He; Peters, Ulrike; Farrall, Martin; Orho-Melander, Marju; Kooperberg, Charles; McPherson, Ruth; Watkins, Hugh; Willer, Cristen J; Hveem, Kristian; Melander, Olle; Kathiresan, Sekar; Abecasis, Gonçalo R

Book ID
123612074
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
632 KB
Volume
46
Category
Article
ISSN
1061-4036

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In anticipation of the availability of next-generation sequencing data, there has been increasing interest in association analysis of rare variants (RVs). Owing to the extremely low frequency of a RV, single variant-based analysis and many existing tests developed for common variants may not be suit