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General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies

✍ Scribed by Lee, Seunggeun; Teslovich, Tanya M.; Boehnke, Michael; Lin, Xihong

Book ID
120435267
Publisher
American Society of Human Genetics
Year
2013
Tongue
English
Weight
408 KB
Volume
93
Category
Article
ISSN
0002-9297

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Recent advances in next-generation sequencing technologies facilitate the detection of rare variants, making it possible to uncover the roles of rare variants in complex diseases. As any single rare variants contain little variation, association analysis of rare variants requires statistical methods