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Raman spectroscopy in investigations of mechanism of binding of human serum albumin to molecular probe fluorescein

✍ Scribed by I.M. Vlasova; A.M. Saletsky

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 107 KB
Volume: 5
Category: Article
ISSN: 1612-2011
DOI: 10.1002/lapl.200810004

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✦ Synopsis

The mechanism of binding of molecular probe fluorescein to molecules of human serum albumin was studied by the Raman spectroscopy method. The position of binding Center on human serum albumin molecule for fluorescein is determined. The amino acid residues of albumin molecule, participating in binding of fluorescein at different pH values of solution, are established. The conformation rearrangements of globules of human serum albumin, taking place at binding of fluorescein at different pH values of solution, are registered.

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