Radiosynthesis of a ligand for studying the glycine transporter: [11C]ALX-5407

✍ Scribed by Hayden T. Ravert; William B. Mathews; Mark A. Klitenick; Dean F. Wong; Robert F. Dannals

• Book ID: 102900828
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: French
• Weight: 967 KB
• Volume: 44
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.453

✦ Synopsis

Abstract

[^11^C]ALX‐5407, R‐N[3‐(4′‐fluorophenyl)‐3‐(4′‐phenylphenoxy)propyl] sarcosine, a chiral glycine transporter 1 antagonist, was labeled with [^11^C]iodomethane by N‐alkylation of methyl ester protected N‐normethyl precursor, ALX‐5536, and subsequent saponification of the methyl ester protecting group. The time for synthesis, purification, and formulation was 33 minutes with an average specific radioactivity of 3909 mCi/µmol (EOS) and average decay corrected radiochemical yield of 8%. Copyright © 2001 John Wiley & Sons, Ltd.