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[11C]GSK931145: A new pet ligand for glycine transporter 1

✍ Scribed by N. Venkatesha Murthy; J. Passchier; R.N. Gunn; G.E. Searle; S. Bullich; M. Suarez; R. Herance; M. Farre; H. Herdon; R. Porter; S. Sutherland; R. Fagg; M. Neve; M. Slifstein; M. Laruelle; A.M. Catafau


Book ID
118491188
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
55 KB
Volume
41
Category
Article
ISSN
1053-8119

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πŸ“œ SIMILAR VOLUMES


Radiosynthesis of a ligand for studying
✍ Hayden T. Ravert; William B. Mathews; Mark A. Klitenick; Dean F. Wong; Robert F. πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 French βš– 967 KB

## Abstract [^11^C]ALX‐5407, R‐__N__[3‐(4′‐fluorophenyl)‐3‐(4′‐phenylphenoxy)propyl] sarcosine, a chiral glycine transporter 1 antagonist, was labeled with [^11^C]iodomethane by N‐alkylation of methyl ester protected N‐normethyl precursor, ALX‐5536, and subsequent saponification of the methyl ester

[11C,127I] Altropane: A highly selective
✍ Alan J. Fischman; Ali A. Bonab; John W. Babich; E. Livni; Nathaniel M. Alpert; P πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 189 KB

The E isomer of (123)I-2beta-carbomethoxy-3beta-(4-fluorophenyl)-N-(1-iodoprop-1-en-3-yl)nortropane (Altropane(R)) shows high affinity (IC(50) = 6.62 +/- 0.78 nmol) and selectivity (DA/5-HT = 25) for DAT sites in the striatum. Recently, dynamic SPECT studies in healthy volunteers and patients with P