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Radiosynthesis and biodistribution of [11C]R107474 as a potential pet ligand for central α2-adrenoceptors

✍ Scribed by M. van der Mey; J. E. Leysen; L. E. J. Kennis; A. D. Windhorst; J. D. M. Herscheid

Book ID
112132597
Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
228 KB
Volume
44
Category
Article
ISSN
0022-2135

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Synthesis of [11C]atipamezole, a potenti
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✍ D. Roeda; H.T. Sipilä; Y. Bramoullé; J. D. Enas; F. Vaufrey; F. Dollé; C. Crouze 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 119 KB

## Abstract The __α__~2~‐adrenergic receptor antagonist atipamezole has been labelled with carbon‐11 using [^11^C]formaldehyde and 2‐ethyl‐2‐oxoacetylindane. Various routes are proposed for the synthesis of the latter: oxidation of 2‐acetyl‐2‐ethylindane, hydrolysis of 2‐diethoxy‐2‐indane and oxida